منابع مشابه
Optimal metabolic pathway activation
This paper deals with temporal enzyme distribution in the activation of biochemical pathways. Pathway activation arises when production of a certain biomolecule is required due to changing environmental conditions. Under the premise that biological systems have been optimized through evolutionary processes, a biologically meaningful optimal control problem is posed. In this setup, the enzyme co...
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There has been increasing recognition of the importance of cellular metabolism and metabolic substrates for the function and differentiation of immune cells. In this study, for the first time to our knowledge, we investigate the metabolic requirements for production of IFN-g by freshly isolated NK cells. Primary murine NK cells mainly use mitochondrial oxidative phosphory-lation at rest and wit...
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Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deac...
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The estimation of parameters in even moderately large biological systems is a significant challenge. This challenge is greatly exacerbated if the mathematical formats of appropriate process descriptions are unknown. To address this challenge, the method of dynamic flux estimation (DFE) was proposed for the analysis of metabolic time series data. Under ideal conditions, the first phase of DFE yi...
متن کاملThe MetaCyc Metabolic Pathway Database
MetaCyc is a metabolic-pathway database (DB) that describes 445 pathways and 1115 enzymes occurring in 158 organisms. As a general reference source on metabolic pathways, MetaCyc serves several purposes in metabolic engineering. It provides an encyclopedic listing of enzymes and their properties to allow a metabolic engineer to find an enzyme whose characteristics solve an engineering problem a...
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ژورنال
عنوان ژورنال: IFAC Proceedings Volumes
سال: 2008
ISSN: 1474-6670
DOI: 10.3182/20080706-5-kr-1001.02130